Jim Parsons left "The Big Bang Theory" and Jesse Williams quit "Grey's Anatomy," but they're not the only famous actors to leave major series.

From shocking cast exits to the most contentious confrontations on set, here are the 13 biggest controversies in "Grey's Anatomy" history.

"Grey's Anatomy" stars Jesse Williams and Sarah Drew have publicly supported the idea of their characters getting a spinoff since 2021.

Pompeo said "Grey's Anatomy" often hits fans "over the head for just one hour" with social issues that should be "threads" of the show.

Oh, 50, got honest with "Squid Game" star Jung Ho-yeon, 27, in a conversation for Variety about the "stress" and "confusion" of fame.

"We're not making out in the elevator," Sarah Drew said of the moment fans realized Japril was reunited as a couple.

"I want to see that. I want to show that. I want to play those scenes," Sarah Drew said about revisiting Japril on a spinoff of "Grey's Anatomy."

The ABC medical drama just aired its season-18 finale. Here's what happened to characters like Meredith Grey and Miranda Bailey by the end.

We're reliving the biggest moments in Jackson and April's relationship before they return to "Grey's Anatomy" for the 400th episode.

Ellen Pompeo recently said that "Grey's Anatomy" could go on "not necessarily with me" but "beyond me."

"You can get pregnant if you don't consent," Pompeo reminds the public in a new PSA about reproductive health.

This "Grey's Anatomy" controversy begins in the writers' room. Here's what we know about Elisabeth Finch and why some aren't believing her story.

Williams' "Grey's Anatomy" costar Ellen Pompeo previously said she's "not trying to find out" what he looks like naked.

"I get it. I'd watch it," Ellen Pompeo told Insider in November when asked about a "Grey's Anatomy" spinoff starring Drew and Williams.

"Oh, if Debbie Allen's going to do it then I can do it,'" Kate Walsh joked about improvising an upcoming "combative" scene on "Grey's Anatomy."

"Had she said that today, she'd be a complete hero," Pompeo said of Katherine Heigl's past controversial comments about "Grey's Anatomy."

Jake Borelli told Insider he recently read the "Grey's Anatomy" season 18 finale and is "still in shock."

"You want good seats, but you want to be up close, but if he's gonna be naked on stage we don't want to be up close," Pompeo explained.

The first show from Rhimes' multi-million-dollar deal with Netflix, "Bridgerton," is back on March 25 after season one became a phenomenon.

The "9-1-1: Lone Star" actor famously turned down the role of Dr. Derek Shepherd to star on the short-lived CBS medical drama "Dr. Vegas" instead.